The Brain Prize Online Seminar Series: Daniela Pietrobon's Brain Prize seminar
The Brain Prize Online Seminar Series: Daniela Pietrobon - Migraine: A disorder of E-I balance?
In 2021 The Brain Prize, the world’s largest award for neuroscience, was awarded to Jes Olesen, Lars Edvinsson, Peter Goadsby, and Michael Moskowitz for their work on the causes and treatment of migraine.
The Brain Prize seminar series on migraine and headache consists of 12 seminars from international leaders in the field including the 2021 Brain Prize winners.
The series will begin in April 2021 and end in March 2022 and covers topics including mechanistic studies in patients and animal models, genetics of migraine, cluster- and post-traumatic headache, and treatment of migraine and headache disorders.
Migraine - a disorder of E-I balance? Insights from genetic mouse models of the disease
Migraine is much more than an episodic headache.
It is a complex brain disorder, characterized by a global dysfunction in multisensory information processing and integration. In a third of patients, the headache is preceded by transient sensory disturbances (aura), whose neurophysiological correlate is cortical spreading depression (CSD).
The molecular, cellular and circuit mechanisms of the primary brain dysfunctions that underlie migraine onset, susceptibility to CSD and altered sensory processing remain largely unknown and are major open issues in the neurobiology of migraine.
enetic mouse models of a rare monogenic form of migraine with aura provide a unique experimental system to tackle these key unanswered questions. I will describe the functional alterations we have uncovered in the cerebral cortex of genetic mouse models and discuss the insights into the cellular and circuit mechanisms of migraines obtained from these findings.
More about professor Daniela Pietrobon, Università di Padova.
The Brain Prize Online Seminar Series Programme:
Note that all the seminars start at 4 PM CET.
Jes Olesen, Denmark| 29 April 2021
Lars Edvinsson, Sweden | 27 May 2021
Peter Goadsby, UK/USA |24 June 2021
Michael Moskowitz, USA | 29 July 2021
Messoud Ashina, Denmark | 25 August 2021
Amy Gelfand, USA | 30 September 2021
Daniela Pietrobon, Italy | 28 October 2021
Nouchine Hadjikhani, USA | 18 November 2021
Amynha Pradhan, USA | 9 December 2021
Arn van den Maagdenberg, Netherlands | 27 January 2022
David Dodick, USA | 24 February 2022
Philip Holland, UK | 24 March 2022