The Brain Prize Online Seminar Series: Jes Olesen's Brain Prize seminar

 

MIGRAINE AND HEADACHE

In 2021 The Brain Prize, the world’s largest award for neuroscience, was awarded to Jes Olesen, Lars Edvinsson, Peter Goadsby, and Michael Moskowitz for their work on the causes and treatment of migraine.
The Brain Prize seminar series on migraine and headache consists of 12 seminars from international leaders in the field including the 2021 Brain Prize winners.

The series will begin in April 2021 and end in March 2022 and covers topics including mechanistic studies in patients and animal models, genetics of migraine, cluster- and post-traumatic headache, and treatment of migraine and headache disorders.

 

A lifelong devotion to headache research has led to many discoveries. First a series of studies of brain blood flow during attacks of migraine. The results showed changes compatible with cortical spreading depression in migraine without aura effectively negating the then prevailing vasospastic/ischemic theory. In migraine without aura no changes in brain blood flow. This difference was crucial for the separation of migraine with aura and migraine without aura in the first and subsequent editions of the international headache classification headed by me.

Then a human migraine provocation model that has elucidated the molecular mechanisms of migraine. Successively we showed in series of papers the importance of nitric oxide, histamine, CGRP, PACAP, and prostanoids. Therapeutic effectiveness of antagonizing these provokers by tonabersat, L-NMMA, CGRP receptor antagonists, and monoclonal antibodies and of NSAIDs. Present and future attempts to put all these signaling mechanisms into a framework but it is not easy. 

The Brain Prize Online Seminar Series Programme:

Note that all the seminars start at 4 PM CET.

Jes Olesen, Denmark􀀑| 29 April 2021
Lars Edvinsson, Sweden |  27 May 2021
Peter Goadsby, UK/USA |􀀑24 June 2021
Michael Moskowitz, USA | 29 July 2021
Messoud Ashina, Denmark | 25 August 2021
Amy Gelfand, USA | 30 September 2021
Daniela Pietrobon, Italy | 28 October 2021
Nouchine Hadjikhani, USA | 18 November 2021
Amynha Pradhan, USA | 9 December 2021
Arn van den Maagdenberg, Netherlands | 27 January 2022
David Dodick, USA | 24 February 2022
Philip Holland, UK | 24 March 2022

Read more about The Brain Prize Seminar Series 2021