Michael Greenberg
Michael Greenberg
Michael Greenberg received a BA in Chemistry from Wesleyan University in 1976, and a Ph.D. in Biochemistry from the Rockefeller University, New York, in 1982. In 1986 he was appointed Assistant Professor in the Department of Microbiology and Genetics at Harvard Medical School, and he was made full Professor in 1994. Since 2008 he has been the Nathan Marsh Pusey Professor of Neurobiology at Harvard Medical School in Boston, MA, USA.
That our sensory experiences shape the structure and function of the brain is one of the profound discoveries in the field of neuroscience in the 20th century. Michael Greenberg’s seminal discoveries of activity- dependent gene transcription have revealed how nature and nurture cooperate to shape mammalian brain development and plasticity. Building on his early observation that neurotransmitter reception triggers the rapid induction of new gene expression, his work has focused on elucidating the nature and role of neuronal transcriptional programs induced in response to extracellular stimuli.
Work in the Greenberg laboratory has characterized the signal transduction pathways linking calcium influx at distal synapses to the neuronal nucleus, uncovered an extensive network of neuronal activity-responsive cis-regulatory elements that coordinate these gene expression changes, and demonstrated significant neuronal cell-type- and species-specific diversity in these transcriptional responses.
These studies have uncovered an important role for activity-dependent transcriptional responses in dynamically sculpting specific aspects of neuronal connectivity. Current work in his laboratory focuses on how these changes contribute to experience-dependent behavioural plasticity and understanding the basis of neurological diseases that arise when these processes have gone awry.
The Brain Prize 2023 is also awarded to:
