Advancing CRISPR Gene Therapy by Lipid Nanoparticles (LNP) Delivery (LNP-CRISPRs)

Associate Professor

Aarhus University

Associate professor Yonglun Luo’s project will establish and streamline the delivery of therapeutic CRISPR mRNAs by lipid nanoparticles (LNP), a well-established mRNA delivery strategy for COVID-19 vaccines.

It will optimize and establish the LNP delivery for different Cas9 variants. Using the optimized LNP-CRISPR method Duchenne Muscular Dystrophy (DMD)-causing mutations in DMD patient skin cells, iPSCs, mouse and pig DMD models, thus streamlining the development and application of CRISPR therapies.

He received a Lundbeck Foundation Ascending Investigator research grant of DKK 5,054,000.