Novel modalities for modulation of glycinergic signaling in the brain

Postdoc

University of Copenhagen

Francesco Bavo, postdoc, Department of Drug Design and Pharmacology, University of Copenhagen, has been awarded a Lundbeck Foundation LF Experiments research grant worth DKK 2,000,000.

The goal of this interdisciplinary project is the development of small molecules, which can selectively induce degradation of the neurotransmitter GlyT1 in vitro and in vivo (PROTACs); and to investigate partial depletion of GlyT1 through genetic manipulation as a novel therapeutic approach for treatment of schizophrenia, epilepsy and stroke.